PMCID: PMC3246854
Dissecting Darwinism
John
Hunter, the acclaimed “father of scientific surgery,” understood human
anatomy through a process of careful dissection. From 1750 to 1793, he
revolutionized modern surgical anatomy through the dissection of
thousands of human samples derived from fresh human cadavers, which came
from fresh graves (1).
He was credited with educating over 2000 surgeons globally based on the
doctrine of observation, experimentation, and application of scientific
evidence, rather than a reliance on potions, humors, and superstitions
to manage disease. The early American surgeons who attended these highly
desired anatomy courses included Philip Syng Physick, William Shippen,
John Morgan, and many others who helped establish the foundations of
American medical education.
John Hunter was also a
brilliant biologist and naturalist, having dissected and stored
thousands of animals and plants. His considerable samples represented
the entire initial display of the Royal College of Surgeons Museum. In
two lengthy volumes, entitled Essays and Observations on Natural History, Anatomy, Physiology, Psychology, and Geology,
he identified the remarkable similarity of muscles and organs between
various species. John Hunter proposed a gradual formation of species
through mutation 70 years before Charles Darwin published his
observations in On the Origin of the Species. Therefore,
history reveals that surgeons are uniquely capable of gathering
information, making observations, and reaching conclusions about
scientific discoveries.
As the scientific community is
faced with new challenges to time-honored conclusions regarding the
origin of the species, the origin of humans, and evolution, it is
appropriate to dissect this new corpus of information with fairness and
modern knowledge. Hence, the purpose of this paper is to review the
arguments that have been leveled against the concept of evolution as
proposed by Charles Darwin and John Hunter, surgeon and biologist
extraordinaire.
Since this review is offered by a
physician and surgeon, it might be appropriate to provide evidence of
qualification and credibility for such a scientific endeavor. Medicine
is a field that attracts some of the brightest minds, based on
competitive test scores and undergraduate performance. Modern premedical
education commonly includes a typical bachelor's of science degree in
biology, chemistry, mathematics, biochemistry, or molecular biology.
Medical education includes 2 years of basic science education in
molecular biology, biochemistry, biology, anatomy, physiology, and
pharmacology, among other topics. Participation in clinical or basic
research is common during medical education or residency.
Physicians
then continue their education by practical application of basic science
into problem-solving situations with the human body. Regarding the human
body, physicians also have an intimate and integrated knowledge of the
complete interrelationships, biochemistry, and molecular processes
involved with various systems. In fact, the physician represents the
penultimate expert on applied molecular pathways as they relate to human
conditions. Many surgeons, including this author, are actively involved
with gene therapy, vaccine therapy, and the latest molecular targeting
based on the incredible breakthroughs in our understanding of the
science of DNA (2–4). Therefore, the physician is indeed an excellent source to dissect evolution based on modern science and applied medicine.
In a 2005 survey of 1472 physicians, almost 78% favored a belief in evolution as an explanation for the origin of the species (5). Among the nation's scientists and biologists, 99% believe in Darwinian evolution (6).
The definition of evolution has changed over the years. However, the
basic tenets of Charles Darwin suggested that random mutations occur and
natural selection continually acts on the surviving mutation, leading
to slight improvements and changes in species over time. Neo-Darwinism
was coined in 1895 and reflected knowledge of reproduction and
recombination, leading to potentially greater shifts in species. The
“modern synthesis” of evolutionary thought was proposed in 1950 to
incorporate the knowledge of genetics, systematics, paleontology, and
other fields. Taken together, the basic concepts recognize that random
mutations occur and natural selection continually acts on the surviving
mutation, leading to improvements and changes in species over time.
These mutations can occur gradually or rapidly via a term called
saltation or punctuated evolution. This process of mutation and natural
selection has been proposed to explain the descent from a common
ancestor, even from the original prokaryocytes billions of years ago. On
the basis of natural selection and time, it has been theorized that
single cellular organisms may have arisen from a primordial mixture of
ancient elements and energy.
Several academic
organizations have developed guideline statements to promote Darwinian
evolution (including neo-Darwinism, modern synthesis, and punctuated
evolution) as the single basic principle to be taught in high schools,
universities, and colleges (7).
School systems have debated the educational merits of Darwinian
evolution and have found themselves in various state and federal courts.
In Kitzmiller v the Dover Area School District, the US
District Court ruled in 2005, among other things, that the school board
could not require teachers to denigrate or disparage the scientific
theory of evolution (8).
In 2010, the Texas State Board of Education accepted testimony for 3
days from scientists and citizens regarding the teaching of evolution.
Representatives of the National Center for Science Education testified
that teaching the weaknesses of evolution would unfairly mark future
high school seniors as poorly prepared to compete for college positions
based on an education that might be considered nonscientific (9).
However, numerous other scientists, citizens, and educators brought
forth evidence that emphasized the weaknesses of Darwinian evolution.
Ultimately, the board took a controversial position and voted to require
future textbooks in the state to explain the weaknesses and the
strengths of Darwinian evolution.
Two specific strengths of Darwinian evolution are generally agreed upon:
- Species adapt to a change in environment (bird beak changes, bacterial resistance, fruit fly experiments). This is called microevolution.
- There is similarity in the DNA across species (called homology).
During the Texas State Board of Education testimony, weaknesses were raised about three issues:
- Limitations of the chemical origin of life data to explain the origin of DNA
- Limitations of mutation and natural selection theories to address the irreducible complexity of the cell
- Limitations of transitional species data to account for the multitude of changes involved in the transition
In the sections below, I discuss these three weaknesses and then provide some concluding thoughts on paradigm shift.
CHEMICAL ORIGIN OF LIFE
In
1953, the field of abiogenesis took a large step forward when Stanley
Miller and Harold Urey reported that a collection of five simple amino
acids could be formed from placing a combination of chemicals in a jar
and subjecting the jar to energy in the form of electricity (10, 11).
This experiment continues to be used in high school and college texts
as the unquestioned fundamental explanation for the origin of life based
on a purely natural process (12). Unfortunately, the experimental conditions of a low-oxygen, nitrogen-rich reducing environment have been refuted by many (13–15). The experiment actually produces a racemic mixture of amino acids that would inhibit the production of useful proteins.
After
Watson and Crick unveiled the double helix nature of DNA in 1953, the
origin-of-life research began to focus on the nucleotides and the
complex chemical processes that might create the energy for the
primitive cell. Modern textbooks expand on the largely debunked
Miller-Urey experiment and further propose that the nucleotides form
together in a primitive environment with explanations that include the
RNA world hypothesis (16), thermogenesis (17), and hypercycles (18).
Unfortunately, the student is not taught that those theories still
require complex and specified information contained in functioning
proteins, which cannot be explained or self-generated (19).
Furthermore, the student is not taught that the four nucleotides do not spontaneously form in nature (20). There is no self-organizing principle that would guide or facilitate alignment of nucleotides (21, 22).
Any experimentally manufactured nucleotides are mixtures of L
(left-oriented) and D (right-oriented) isomers. Since DNA is composed of
only D isomers, the probability of alignment of thousands of specified D
isomers becomes even more remote (23, 24).
Even if there was a self-organizing pattern, the probability of even a
short strand of nucleotides occurring in a precisely specified linear
pattern that would code for even the smallest single-celled organism
with approximately 250 genes has been calculated to be 1 in 10150—1 in 1070 less than the chance of finding a particular electron in the entire universe (25).
In
addition to the lack of evidence for self-formation of proteins or
nucleotides, the fundamental and insurmountable problem with Darwinian
evolution lies in the remarkable complexity and inherent information
contained within DNA (26).
Modern scientists have unraveled the incomparable elegance and
protein-coding information of DNA over the past 50 years. The
fundamental blueprint of the cell is found in the DNA, which is composed
of four different nucleotides (adenine, cytosine, thymine, and
guanine). The individual human cell has 5 billion nucleotides arranged
in precise order, allowing for the coding and formation of 25,000
complex enzymes and proteins.
This protein development process involves at least 200 unique proteins and cofactors (Figure 1).
Steps in protein synthesis. Reproduced with permission from Genentech's Access Excellence.
First, transcription involves the copying of the DNA into a matching
strand of messenger RNA composed of similar nucleotides and slightly
different sugar molecules. Second, the messenger RNA migrates out of the
nucleus into the cytoplasm and is translated into a protein in a
ribosome, which coordinates the delivery of a specific transfer
RNA-amino acid moiety. A codon, composed of three specific nucleotides,
allows for the integration of a single specific amino acid into a long
series of amino acids, which then folds into a specific
three-dimensional structure called a protein. The 25,000 enzymes and
proteins being coded for in each cell of the human body have thousands
of minute functions, including signal transduction from the surface,
maintenance of specific electrolyte concentrations within very tight
limits, storage and utilization of energy, manufacture of proteins, and
cell division. In summary, the DNA within each cell is responsible for
the production and processing of carefully orchestrated and interrelated
functions within the cell. As an analogy, DNA far surpasses the
complexity of the blueprints and production of a 30-story building with
elevators, electricity, plumbing, computers, and air-conditioning.
Based
on an awareness of the inexplicable coded information in DNA, the
inconceivable self-formation of DNA, and the inability to account for
the billions of specifically organized nucleotides in every single cell,
it is reasonable to conclude that there are severe weaknesses in the
theory of gradual improvement through natural selection (Darwinism) to
explain the chemical origin of life. Furthermore, Darwinian evolution
and natural selection could not have been causes of the origin of life,
because they require replication to operate, and there was no
replication prior to the origin of life.
IRREDUCIBLE COMPLEXITY OF CELLULAR SYSTEMS
The
physician studies and understands the enormous complexity of the human
body and the human cell. Some aspects of Darwinian evolution in the
human body are readily agreed upon—for example, mutation and natural
selection acting to influence malarial resistance, skin characteristics,
and many other minor changes within the species.
However, the origin of
and explanation for the formation of complex organs remains unclear.
Starting from a single germ-line cell, the DNA is sufficient to code for
and control development of 50 trillion cells that organize into complex
organs based on expression of different sections of DNA, leading to
entirely different “factories” that have such diverse functions as the
liver, the brain, the heart, and the eye.
Proponents of
mutation and natural selection point to a scientific publication
regarding eye evolution. Nilsson offered a simulation explaining how a
light-sensitive spot with a light-absorbing layer gradually transitioned
to a cup, then a hemisphere filled with a transparent substance, and
then, with the ends brought together, an aperture (27).
Natural selection would theoretically lead to a gradually improved
species, which would evidently mate and create progressively better
eyes, including the natural formation of a lens, a retina, and the
neural transmission to the brain.
However, biochemists
have shown that even a simple light-sensitive spot requires a complex
array of enzyme systems. When light strikes the retina, a photon
interacts with a molecule called 11-cis-retinal, which rearranges within
picoseconds to trans-retinal. The change in the shape of the retinal
molecule forces a change in the shape of the protein rhodopsin. The
protein then changes to metarhodopsin II and sticks to another protein,
called transducin. This process requires energy in the form of GTP,
which binds to transducin. GTP-transducin-metarhodopsin II then binds to
a protein called phosphodiesterase, located on the cell wall. This
affects the cGMP levels within the cell, leading to a signal that then
goes to the brain.
The recognition of this signal in the brain and
subsequent interpretation involve numerous other proteins and enzymes
and biochemical reactions within the brain cells. Thus, each of these
enzymes and proteins must exist for the system to work properly. Many
other mathematical and logistical weaknesses to the Nilsson example of
eye evolution have been uncovered (28).
In summary, the eye is incredibly complex. Since it is unreasonable to
expect self-formation of the enzymes in perfect proportion
simultaneously, eye function represents a system that could not have
arisen by gradual mutations.
The concept of irreducible
complexity suggests that all elements of a system must be present
simultaneously rather than evolve through a stepwise, sequential
improvement, as theorized by Darwinian evolution (29).
Within each individual cell, there are tens of thousands of additional
interrelated complex actions, enzymatic steps, and processes that
automatically maintain cellular homeostasis, protein transport,
self-protection, and replication. The fact that these irreducibly
complex systems are specifically coded through DNA adds another layer of
complexity called “specified complexity” (30).
Geoffrey Simmons, MD, has presented 17 examples within the human body
of irreducibly complex systems that could not have formed by sequential
or simultaneous mutation, since all components must be present to work
correctly (31).
These infinitely complex systems include vision, balance, the
respiratory system, the circulatory system, the immune system, the
gastrointestinal system, the skin, the endocrine system, and taste.
In
addition, virtually every aspect of human physiology has regulatory
elements, feedback loops, and developmental components that require
thousands of interacting genes leading to specified protein expression.
These functions and the corresponding specification of the DNA code are
too inconceivably complex to have arisen by accidental mutation or
change.
When John Hunter and Charles
Darwin saw similarities in muscles and body structure across species,
they had no knowledge of the enormous complexity inherent within those
organs.
In the 1850s, Hunter and Darwin might have accomplished the same
simulation as Nilsson with the simple alignment of a series of eyes
from less complex to complex and the assumption that some sort of
gradual evolution over billions of years would be responsible. Modern
scientists applying knowledge of the intrinsic complexity within each
cell would understand that each sequential mutation in the DNA within
the eyeball would require simultaneous mutations in bone structure,
nerves, brain function, and hundreds of proteins and cell signaling
pathways to make even the smallest change in only one organ system.
Such
changes would require far more than could be expected from random
mutation and natural selection. Since these systems are irreducibly
complex and individual mutations in one organ would not be beneficial
for the organism, these random mutations in all aspects of vision would
need to occur simultaneously. Therefore, the human body represents an
irreducibly complex system on a cellular and an organ/system basis.
TRANSITIONAL SPECIES DATA
The
transitional species from primitive primates to man have been
illustrated in textbooks for over 100 years. These drawings form the
visual imagery that supports Darwinian evolution for high school
students, university students, medical students, and the public.
However, honest dissent exists in the accuracy of most of the
transitional prehominoids, with many found to be frauds or animal
species. Reconstructions based on fragmentary and scattered bones,
surface bones, and gross morphologic features are limited.
Anomalous
findings of stone tools, bones, and hundreds of other artifacts have
suggested that Homo sapiens were actually present 2 to 7 million years ago (at the same time as early proposed transitional species) (32).
Certainly, there has been no additional transitional mutant or species change from the first generally accepted Homo sapiens
over 200,000 years ago.
The DNA homology between ape and man has been
reported to be 96% when considering only the current protein-mapping
sequences, which represent only 2% of the total genome. However, the
actual similarity of the DNA is approximately 70% to 75% when
considering the full genome, including the previously presumed “junk
DNA,” which has now been demonstrated to code for supporting elements in
transcription or expression (33).
The 25% difference represents almost 35 million single nucleotide changes and 5 million insertions or deletions (34).
The ape to human species change would require an incredibly rapid rate
of mutation leading to formation of new DNA, thousands of new proteins,
and untold cellular, neural, digestive, and immune-related changes in
DNA, which would code for the thousands of new functioning proteins.
This rate of mutation has never been observed in any viral, bacterial,
or other organism.
The estimation for DNA random mutations that would
lead to intelligence in humans is beyond calculation. Therefore, the
recently discovered molecular differences between apes and humans make
the prospect of simple random mutation leading to a new species of Homo sapiens largely improbable (35).
The 2004 transitional species between water- and land-based creatures (Tiktaalik roseae) was based on a recovered bone fragment representing the wrist structure that would be necessary for moving on land (36) (Figure 2).
Even though this species has been disparaged by scientific circles, it
is important to realize that any transition from a water-based organism
to an air-breathing land-based organism would also require thousands of
simultaneous mutations in the basic physiology of the eyes, nose,
alimentary system, lungs, muscles, and bones. This would entail
thousands of discrete mutations in the DNA, which would code for the
underlying changes in the individual cellular systems and enzymes
responsible for the changes. A transitional species change would also
require a simultaneous change in another organism, allowing for
reproduction and duplication of the markedly mutated DNA.
Figure 2
The Tiktaalik roseae proposed as the missing link between water-based and land-based organisms. Reprinted with permission from the New York Times.
The
transitional species concept has been most extensively studied through
invertebrate species of plants, shells, and mollusks in carefully
preserved fossil fields in Japan, Malaysia, and Asia. Thousands of
specimens were available at the time of Darwin. Millions of specimens
have been classified and studied in the past 50 years. It is remarkable
to note that each of these fossil beds shows a virtual explosion of
nearly all phyla (35/40) of the animal kingdom over a relatively short
period during the Cambrian era 525 to 530 million years ago (37) (Figure 3). Since that time, there has been occasional species extinction, but only rare new phyla have been convincingly identified (38).
The seminal paper from paleoanthropologists J. Valentine and D. H.
Erwin notes that the absence of transitional species for any of the
Cambrian phyla limits the neo-Darwinian explanation for evolution (39).
Figure 3
The
origin of the phyla: the fossil evidence. Contrary to both Darwinian
gradualism and punctuated equilibria theory, the vast majority of phyla
appear abruptly with low species diversity. The disparity of the higher
taxa precedes the diversity of the ...
Finally,
bacterial evolution or adaptation offers an excellent opportunity to
see mutation in a species with rapid cell division. Evolutionary biology
can be modeled over a relatively short time (30 years), while observing
DNA mutations over 1020 generations (40).
This is analogous to observing mutations in man or any mammal over 200
million years.
A recent review of numerous papers related to viral and
bacterial evolution over the past 40 years revealed that the vast
majority of mutations led to a loss or slight modification of function
that conferred resistance or survival benefit (41).
These specific mutations included simple deletions, substitutions,
frame shift mutations, inversion, and insertion. No gain-in-function
mutations were observed in any of the long-term bacterial evolution
studies. There were only two gain-of-function mutations in the long-term
viral evolution studies. The absence of mutations leading to a single
new protein suggests the difficulty of using mutation to explain the
development of numerous new proteins coded specifically by thousands of
nucleotides in a precise order, interacting with numerous other enzymes
in a simultaneous fashion to accomplish a single cellular action such as
the cellular manufacture of a single nucleotide.
The
complexity of creating two sequential or simultaneous mutations that
would confer improved survival has been studied in the malaria parasite
when exposed to chloroquine. The actual incidence of two base-pair
mutations leading to two changed amino acids leading to resistance has
been shown to be 1 in 1020 cases (42). To better understand this incidence, the likelihood that Homo sapiens
would achieve any single mutation of the kind required for malaria to
become resistant to chloroquine (a simple shift of two amino acids)
would be 100 million times 10 million years (many times the age of the
universe). This example has been used to further explain the difficulty
in managing more than one mutation to achieve benefit.
In
all fairness, there is convincing evidence, that is widely
acknowledged, that random mutation and natural adaptation (Darwinian
evolution) does occur within species, leading to minor changes in areas
such as beak size, skin pigmentation, or antibiotic resistance. Some of
these changes involve a simple biologic survival advantage for a
population, without a mutation in DNA. Others might be influenced by a
single deletion or insertion within the DNA strand.
However, the modern
evolution data do not convincingly support a transition from a fish to
an amphibian, which would require a massive amount of new enzymes,
protein systems, organ systems, chromosomes, and formation of new
strands of specifically coding DNA.
Even with thousands of billions of
generations, experience shows that new complex biological features that
require multiple mutations to confer a benefit do not arise by natural
selection and random mutation. New genes are difficult to evolve. The
bacteria do not form into other species. A reliance on gross morphologic
appearances, as with fossils, drawings, and bone reconstructions, is
severely inadequate compared to an understanding of the complexity of
the DNA and coding that would have been required to mutate from a fish
to an amphibian or from a primitive primate to a human.
PARADIGM SHIFT
In his landmark book, The Structure of Scientific Revolutions, Massachusetts Institute of Technology Professor Thomas S. Kuhn gave the term paradigm
its contemporary meaning when he used it to describe universally
recognized scientific achievements that, for a time, provide model
problems and solutions to a community of practitioners (43).
A paradigm shift can be heralded by the occurrence of “counterinstances
or anomalies,” which represent exceptions of the logic or exaggerations
of the evidence.
According to Kuhn, these shifts lead to conflict,
debate, and great resistance, even with accusations that the new
theorists have ignored “science.”
Examples of these gradual paradigm
shifts, which began as chinks in the established armor of science,
include Copernicus versus Ptolemy in astronomy, Lavoisier versus
Priestly in gases, and Einstein versus Newton in relative dynamics.
The
primary conflicts or anomalies with neo-Darwinian evolution lie in the
failure of mutation and natural selection to account for the formation
of DNA, the information of DNA, or the complexity of the human cell.
In
all fairness, many physicians, medical students, and college students
have not been shown the weakness of Darwinian evolution.
They haven't
been shown the failure of the Miller-Urey experiments to explain DNA,
RNA, or protein formation; the paucity of fossil data; or the
refutations of transitional species based on a growing biochemical
understanding of complex systems and the limits of DNA mutation to
account for the formation of new DNA, new chromosomes, and therefore new
species.
In contrast, how is it possible that the
majority of National Academy of Science members (who should know the
above weaknesses) fully believe that random mutation and natural
selection can explain the origin of DNA and the subsequent generation of
a vast array of protein systems within complex cells? It is possible
that the biologist, the paleontologist, and the anthropologist are each
studying a small portion of the picture and do not have the education
and training to see the full picture. More likely, their previous
research relies on the established paradigm of Darwinian evolution to
provide structure for their work. As the limitations of existing
paradigms become apparent, adoption of a new paradigm typically requires
at least a full generation, since existing practitioners and scientists
often hold on to the old paradigm.
When the Texas
State Board of Education voted to recognize the weaknesses of Darwinian
evolution in explaining the origin of the species, it was a result of 3
full days of intense debate and scientific dispute. In 2011, when new
textbooks were presented to the State Board of Education, 9 out of 10
failed to provide the mandated supplementary curricula, which would
include both positive and negative aspects of evolution (44).
Moreover, several of the textbooks continued to incorrectly promote the
debunked Miller-Urey origin of life experiment, the long-discredited
claims about nonfunctional appendix and tonsils, and the fraudulent
embryo drawings from Ernst Haeckel. In essence, current biology
students, aspiring medical students, and future scientists are not being
taught the whole story. Rather, evidence suggests that they continue to
receive incorrect and incomplete material that exaggerates the effect
of random mutation and natural selection to account for DNA, the cell,
or the transition from species to species.
The Texas
State Board of Education guidelines do not propose teaching any other
alternatives to Darwinian evolution. Rather, the students of tomorrow
and teachers of today should appropriately recognize that there are
weaknesses that have been pointed out by reasonable scientists.
In this
dissection of Darwinism, we have cut into the weaknesses of the fossil
evidence for human evolution, the failure of the fossil data to
demonstrate substantial transition species, and the awareness of the
sudden formation of most species in a short window of time, with no
significant subsequent variation. More importantly, this
physician-perspective article emphasizes the extreme impossibility of
the natural formation or self-formation of billions of nucleotides in a
specific sequence, allowing for the coding of RNA and proteins in a
complex cell with thousands of interrelated and irreducibly complex
functions.
The article also enlightens the reader regarding the
conflicts and difficulty of using natural selection and mutation to
explain the simultaneous or sequential changes in cellular DNA,
involving entirely new strands of DNA and thousands of new proteins,
which are necessary for the formation of new species.
John
Hunter and Charles Darwin were limited to gross observation of physical
appearance. The human cell appeared to be a glob of jelly under a
primitive microscope. Both scientists observed mutation and adaptation,
which clearly exist today.
For almost 150 years following their
proposal, thousands of articles and biology departments across the world
made observations based on the paradigm of random mutation and natural
selection to account for changes within species. These changes are
uncontested truths.
However, regarding the origin of the species and
life (DNA), even Darwin commented, “If it could be shown that complex
systems could not arise by small sequential steps, then my theory would
completely break down.”
Irreducibly complex systems involving thousands
of interrelated specifically coded enzymes do exist in every organ of
the human body.
At an absolute minimum, the inconceivable self-formation
of DNA and the inability to explain the incredible information
contained in DNA represent fatal defects in the concept of mutation and
natural selection to account for the origin of life and the origin of
DNA.
As new theories emerge that explain the origin of life, the
inevitable emotional accusations of heresy and ignorance are not
surprising in a period of scientific revolution. It is therefore time to
sharpen the minds of students, biologists, and physicians for the
possibility of a new paradigm.
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