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Showing posts with label SCIENCE. Show all posts

Wednesday, May 24, 2017

David Berlinski : All Those Darwinian Doubts

All Those Darwinian Doubts

David Berlinski  
 
March 9, 2005


The defense of Darwin's theory of evolution has now fallen into the hands of biologists who believe in suppressing criticism when possible and ignoring it when not. It is not a strategy calculated in induce confidence in the scientific method. A paper published recently in the Proceedings of the Biological Society of Washington concluded that the events taking place during the Cambrian era could best be understood in terms of an intelligent design—hardly a position unknown in the history of western science. The paper was, of course, peer-reviewed by three prominent evolutionary biologists. Wise men attend to the publication of every one of the Proceeding's papers, but in the case of Steven Meyer's "The origin of biological information and the higher taxonomic categories," the Board of Editors was at once given to understand that they had done a bad thing. Their indecent capitulation followed at once.

Publication of the paper, they confessed, was a mistake. It would never happen again. It had barely happened at all. And peer review?

The hell with it.

"If scientists do not oppose antievolutionism," Eugenie Scott, the Executive Director of the National Center for Science Education, remarked, "it will reach more people with the mistaken idea that evolution is scientifically weak." Scott's understanding of "opposition" had nothing to do with reasoned discussion. It had nothing to do with reason at all. Discussing the issue was out of the question. Her advice to her colleagues was considerably more to the point: "Avoid debates."

Everyone else had better shut up.

In this country, at least, no one is ever going to shut up, the more so since the case against Darwin's theory retains an almost lunatic vitality.

Look — The suggestion that Darwin's theory of evolution is like theories in the serious sciences — quantum electrodynamics, say — is grotesque. Quantum electrodynamics is accurate to thirteen unyielding decimal places. Darwin's theory makes no tight quantitative predictions at all.

Look — Field studies attempting to measure natural selection inevitably report weak to non-existent selection effects.

Look — Darwin's theory is open at one end since there are no plausible account for the origins of life.

Look — The astonishing and irreducible complexity of various cellular structures has not yet successfully been described, let alone explained.

Look — A great many species enter the fossil record trailing no obvious ancestors and depart for Valhalla leaving no obvious descendents.

Look — Where attempts to replicate Darwinian evolution on the computer have been successful, they have not used classical Darwinian principles, and where they have used such principles, they have not been successful.

Look — Tens of thousands of fruit flies have come and gone in laboratory experiments, and every last one of them has remained a fruit fly to the end, all efforts to see the miracle of speciation unavailing.

Look — The remarkable similarity in the genome of a great many organisms suggests that there is at bottom only one living system; but how then to account for the astonishing differences between human beings and their near relatives — differences that remain obvious to anyone who has visited a zoo?

But look again — If the differences between organisms are scientifically more interesting than their genomic similarities, of what use is Darwin's theory since its otherwise mysterious operations take place by genetic variations?
These are hardly trivial questions. Each suggests a dozen others. These are hardly circumstances that do much to support the view that there are "no valid criticisms of Darwin's theory," as so many recent editorials have suggested.

Serious biologists quite understand all this. They rather regard Darwin's theory as an elderly uncle invited to a family dinner. The old boy has no hair, he has no teeth, he is hard of hearing, and he often drools. Addressing even senior members at table as Sonny, he is inordinately eager to tell the same story over and over again.

But he's family. What can you do?

David Berlinski holds a Ph.D. from Princeton University. He is the author of On Systems Analysis, A Tour of the Calculus, The Advent of the Algorithm, Newton's Gift, The Secrets of the Vaulted Sky, and, most recently, Infinite Ascent: A Short History of Mathematics. He is a senior fellow with Discovery Institute's Center for Science and Culture.


http://www.discovery.org/a/2450

Tuesday, May 23, 2017

Joseph A. Kuhn : Dissecting Darwinism

Dissecting Darwinism



John Hunter, the acclaimed “father of scientific surgery,” understood human anatomy through a process of careful dissection. From 1750 to 1793, he revolutionized modern surgical anatomy through the dissection of thousands of human samples derived from fresh human cadavers, which came from fresh graves (1). He was credited with educating over 2000 surgeons globally based on the doctrine of observation, experimentation, and application of scientific evidence, rather than a reliance on potions, humors, and superstitions to manage disease. The early American surgeons who attended these highly desired anatomy courses included Philip Syng Physick, William Shippen, John Morgan, and many others who helped establish the foundations of American medical education.
John Hunter was also a brilliant biologist and naturalist, having dissected and stored thousands of animals and plants. His considerable samples represented the entire initial display of the Royal College of Surgeons Museum. In two lengthy volumes, entitled Essays and Observations on Natural History, Anatomy, Physiology, Psychology, and Geology, he identified the remarkable similarity of muscles and organs between various species. John Hunter proposed a gradual formation of species through mutation 70 years before Charles Darwin published his observations in On the Origin of the Species. Therefore, history reveals that surgeons are uniquely capable of gathering information, making observations, and reaching conclusions about scientific discoveries.

As the scientific community is faced with new challenges to time-honored conclusions regarding the origin of the species, the origin of humans, and evolution, it is appropriate to dissect this new corpus of information with fairness and modern knowledge. Hence, the purpose of this paper is to review the arguments that have been leveled against the concept of evolution as proposed by Charles Darwin and John Hunter, surgeon and biologist extraordinaire.
Since this review is offered by a physician and surgeon, it might be appropriate to provide evidence of qualification and credibility for such a scientific endeavor. Medicine is a field that attracts some of the brightest minds, based on competitive test scores and undergraduate performance. Modern premedical education commonly includes a typical bachelor's of science degree in biology, chemistry, mathematics, biochemistry, or molecular biology. Medical education includes 2 years of basic science education in molecular biology, biochemistry, biology, anatomy, physiology, and pharmacology, among other topics. Participation in clinical or basic research is common during medical education or residency.

 Physicians then continue their education by practical application of basic science into problem-solving situations with the human body. Regarding the human body, physicians also have an intimate and integrated knowledge of the complete interrelationships, biochemistry, and molecular processes involved with various systems. In fact, the physician represents the penultimate expert on applied molecular pathways as they relate to human conditions. Many surgeons, including this author, are actively involved with gene therapy, vaccine therapy, and the latest molecular targeting based on the incredible breakthroughs in our understanding of the science of DNA (24). Therefore, the physician is indeed an excellent source to dissect evolution based on modern science and applied medicine.

In a 2005 survey of 1472 physicians, almost 78% favored a belief in evolution as an explanation for the origin of the species (5). Among the nation's scientists and biologists, 99% believe in Darwinian evolution (6). The definition of evolution has changed over the years. However, the basic tenets of Charles Darwin suggested that random mutations occur and natural selection continually acts on the surviving mutation, leading to slight improvements and changes in species over time. Neo-Darwinism was coined in 1895 and reflected knowledge of reproduction and recombination, leading to potentially greater shifts in species. The “modern synthesis” of evolutionary thought was proposed in 1950 to incorporate the knowledge of genetics, systematics, paleontology, and other fields. Taken together, the basic concepts recognize that random mutations occur and natural selection continually acts on the surviving mutation, leading to improvements and changes in species over time. These mutations can occur gradually or rapidly via a term called saltation or punctuated evolution. This process of mutation and natural selection has been proposed to explain the descent from a common ancestor, even from the original prokaryocytes billions of years ago. On the basis of natural selection and time, it has been theorized that single cellular organisms may have arisen from a primordial mixture of ancient elements and energy.

Several academic organizations have developed guideline statements to promote Darwinian evolution (including neo-Darwinism, modern synthesis, and punctuated evolution) as the single basic principle to be taught in high schools, universities, and colleges (7). School systems have debated the educational merits of Darwinian evolution and have found themselves in various state and federal courts. In Kitzmiller v the Dover Area School District, the US District Court ruled in 2005, among other things, that the school board could not require teachers to denigrate or disparage the scientific theory of evolution (8). In 2010, the Texas State Board of Education accepted testimony for 3 days from scientists and citizens regarding the teaching of evolution. Representatives of the National Center for Science Education testified that teaching the weaknesses of evolution would unfairly mark future high school seniors as poorly prepared to compete for college positions based on an education that might be considered nonscientific (9). However, numerous other scientists, citizens, and educators brought forth evidence that emphasized the weaknesses of Darwinian evolution. Ultimately, the board took a controversial position and voted to require future textbooks in the state to explain the weaknesses and the strengths of Darwinian evolution.

Two specific strengths of Darwinian evolution are generally agreed upon:
  1. Species adapt to a change in environment (bird beak changes, bacterial resistance, fruit fly experiments). This is called microevolution.
  2. There is similarity in the DNA across species (called homology).
During the Texas State Board of Education testimony, weaknesses were raised about three issues:
  1. Limitations of the chemical origin of life data to explain the origin of DNA
  2. Limitations of mutation and natural selection theories to address the irreducible complexity of the cell
  3. Limitations of transitional species data to account for the multitude of changes involved in the transition
In the sections below, I discuss these three weaknesses and then provide some concluding thoughts on paradigm shift.

CHEMICAL ORIGIN OF LIFE

In 1953, the field of abiogenesis took a large step forward when Stanley Miller and Harold Urey reported that a collection of five simple amino acids could be formed from placing a combination of chemicals in a jar and subjecting the jar to energy in the form of electricity (10, 11). This experiment continues to be used in high school and college texts as the unquestioned fundamental explanation for the origin of life based on a purely natural process (12). Unfortunately, the experimental conditions of a low-oxygen, nitrogen-rich reducing environment have been refuted by many (1315). The experiment actually produces a racemic mixture of amino acids that would inhibit the production of useful proteins.

After Watson and Crick unveiled the double helix nature of DNA in 1953, the origin-of-life research began to focus on the nucleotides and the complex chemical processes that might create the energy for the primitive cell. Modern textbooks expand on the largely debunked Miller-Urey experiment and further propose that the nucleotides form together in a primitive environment with explanations that include the RNA world hypothesis (16), thermogenesis (17), and hypercycles (18). Unfortunately, the student is not taught that those theories still require complex and specified information contained in functioning proteins, which cannot be explained or self-generated (19). 
Furthermore, the student is not taught that the four nucleotides do not spontaneously form in nature (20). There is no self-organizing principle that would guide or facilitate alignment of nucleotides (21, 22). 
Any experimentally manufactured nucleotides are mixtures of L (left-oriented) and D (right-oriented) isomers. Since DNA is composed of only D isomers, the probability of alignment of thousands of specified D isomers becomes even more remote (23, 24). 
Even if there was a self-organizing pattern, the probability of even a short strand of nucleotides occurring in a precisely specified linear pattern that would code for even the smallest single-celled organism with approximately 250 genes has been calculated to be 1 in 10150—1 in 1070 less than the chance of finding a particular electron in the entire universe (25).

In addition to the lack of evidence for self-formation of proteins or nucleotides, the fundamental and insurmountable problem with Darwinian evolution lies in the remarkable complexity and inherent information contained within DNA (26). 

 Modern scientists have unraveled the incomparable elegance and protein-coding information of DNA over the past 50 years. The fundamental blueprint of the cell is found in the DNA, which is composed of four different nucleotides (adenine, cytosine, thymine, and guanine). The individual human cell has 5 billion nucleotides arranged in precise order, allowing for the coding and formation of 25,000 complex enzymes and proteins.

This protein development process involves at least 200 unique proteins and cofactors (Figure 1)


 Steps in protein synthesis. Reproduced with permission from Genentech's Access Excellence.

First, transcription involves the copying of the DNA into a matching strand of messenger RNA composed of similar nucleotides and slightly different sugar molecules. Second, the messenger RNA migrates out of the nucleus into the cytoplasm and is translated into a protein in a ribosome, which coordinates the delivery of a specific transfer RNA-amino acid moiety. A codon, composed of three specific nucleotides, allows for the integration of a single specific amino acid into a long series of amino acids, which then folds into a specific three-dimensional structure called a protein. The 25,000 enzymes and proteins being coded for in each cell of the human body have thousands of minute functions, including signal transduction from the surface, maintenance of specific electrolyte concentrations within very tight limits, storage and utilization of energy, manufacture of proteins, and cell division. In summary, the DNA within each cell is responsible for the production and processing of carefully orchestrated and interrelated functions within the cell. As an analogy, DNA far surpasses the complexity of the blueprints and production of a 30-story building with elevators, electricity, plumbing, computers, and air-conditioning.

Based on an awareness of the inexplicable coded information in DNA, the inconceivable self-formation of DNA, and the inability to account for the billions of specifically organized nucleotides in every single cell, it is reasonable to conclude that there are severe weaknesses in the theory of gradual improvement through natural selection (Darwinism) to explain the chemical origin of life. Furthermore, Darwinian evolution and natural selection could not have been causes of the origin of life, because they require replication to operate, and there was no replication prior to the origin of life.

IRREDUCIBLE COMPLEXITY OF CELLULAR SYSTEMS

The physician studies and understands the enormous complexity of the human body and the human cell. Some aspects of Darwinian evolution in the human body are readily agreed upon—for example, mutation and natural selection acting to influence malarial resistance, skin characteristics, and many other minor changes within the species. 
However, the origin of and explanation for the formation of complex organs remains unclear. Starting from a single germ-line cell, the DNA is sufficient to code for and control development of 50 trillion cells that organize into complex organs based on expression of different sections of DNA, leading to entirely different “factories” that have such diverse functions as the liver, the brain, the heart, and the eye.

Proponents of mutation and natural selection point to a scientific publication regarding eye evolution. Nilsson offered a simulation explaining how a light-sensitive spot with a light-absorbing layer gradually transitioned to a cup, then a hemisphere filled with a transparent substance, and then, with the ends brought together, an aperture (27). Natural selection would theoretically lead to a gradually improved species, which would evidently mate and create progressively better eyes, including the natural formation of a lens, a retina, and the neural transmission to the brain.

However, biochemists have shown that even a simple light-sensitive spot requires a complex array of enzyme systems. When light strikes the retina, a photon interacts with a molecule called 11-cis-retinal, which rearranges within picoseconds to trans-retinal. The change in the shape of the retinal molecule forces a change in the shape of the protein rhodopsin. The protein then changes to metarhodopsin II and sticks to another protein, called transducin. This process requires energy in the form of GTP, which binds to transducin. GTP-transducin-metarhodopsin II then binds to a protein called phosphodiesterase, located on the cell wall. This affects the cGMP levels within the cell, leading to a signal that then goes to the brain. 
The recognition of this signal in the brain and subsequent interpretation involve numerous other proteins and enzymes and biochemical reactions within the brain cells. Thus, each of these enzymes and proteins must exist for the system to work properly. Many other mathematical and logistical weaknesses to the Nilsson example of eye evolution have been uncovered (28). In summary, the eye is incredibly complex. Since it is unreasonable to expect self-formation of the enzymes in perfect proportion simultaneously, eye function represents a system that could not have arisen by gradual mutations.

The concept of irreducible complexity suggests that all elements of a system must be present simultaneously rather than evolve through a stepwise, sequential improvement, as theorized by Darwinian evolution (29). 
Within each individual cell, there are tens of thousands of additional interrelated complex actions, enzymatic steps, and processes that automatically maintain cellular homeostasis, protein transport, self-protection, and replication. The fact that these irreducibly complex systems are specifically coded through DNA adds another layer of complexity called “specified complexity” (30). 
 Geoffrey Simmons, MD, has presented 17 examples within the human body of irreducibly complex systems that could not have formed by sequential or simultaneous mutation, since all components must be present to work correctly (31). These infinitely complex systems include vision, balance, the respiratory system, the circulatory system, the immune system, the gastrointestinal system, the skin, the endocrine system, and taste. 
In addition, virtually every aspect of human physiology has regulatory elements, feedback loops, and developmental components that require thousands of interacting genes leading to specified protein expression. These functions and the corresponding specification of the DNA code are too inconceivably complex to have arisen by accidental mutation or change.

When John Hunter and Charles Darwin saw similarities in muscles and body structure across species, they had no knowledge of the enormous complexity inherent within those organs. 
In the 1850s, Hunter and Darwin might have accomplished the same simulation as Nilsson with the simple alignment of a series of eyes from less complex to complex and the assumption that some sort of gradual evolution over billions of years would be responsible. Modern scientists applying knowledge of the intrinsic complexity within each cell would understand that each sequential mutation in the DNA within the eyeball would require simultaneous mutations in bone structure, nerves, brain function, and hundreds of proteins and cell signaling pathways to make even the smallest change in only one organ system. 
Such changes would require far more than could be expected from random mutation and natural selection. Since these systems are irreducibly complex and individual mutations in one organ would not be beneficial for the organism, these random mutations in all aspects of vision would need to occur simultaneously. Therefore, the human body represents an irreducibly complex system on a cellular and an organ/system basis.

TRANSITIONAL SPECIES DATA

The transitional species from primitive primates to man have been illustrated in textbooks for over 100 years. These drawings form the visual imagery that supports Darwinian evolution for high school students, university students, medical students, and the public. 
However, honest dissent exists in the accuracy of most of the transitional prehominoids, with many found to be frauds or animal species. Reconstructions based on fragmentary and scattered bones, surface bones, and gross morphologic features are limited. 
Anomalous findings of stone tools, bones, and hundreds of other artifacts have suggested that Homo sapiens were actually present 2 to 7 million years ago (at the same time as early proposed transitional species) (32). 
Certainly, there has been no additional transitional mutant or species change from the first generally accepted Homo sapiens over 200,000 years ago. 
The DNA homology between ape and man has been reported to be 96% when considering only the current protein-mapping sequences, which represent only 2% of the total genome. However, the actual similarity of the DNA is approximately 70% to 75% when considering the full genome, including the previously presumed “junk DNA,” which has now been demonstrated to code for supporting elements in transcription or expression (33). 
The 25% difference represents almost 35 million single nucleotide changes and 5 million insertions or deletions (34). The ape to human species change would require an incredibly rapid rate of mutation leading to formation of new DNA, thousands of new proteins, and untold cellular, neural, digestive, and immune-related changes in DNA, which would code for the thousands of new functioning proteins. This rate of mutation has never been observed in any viral, bacterial, or other organism. 
The estimation for DNA random mutations that would lead to intelligence in humans is beyond calculation. Therefore, the recently discovered molecular differences between apes and humans make the prospect of simple random mutation leading to a new species of Homo sapiens largely improbable (35).
The 2004 transitional species between water- and land-based creatures (Tiktaalik roseae) was based on a recovered bone fragment representing the wrist structure that would be necessary for moving on land (36) (Figure 2). Even though this species has been disparaged by scientific circles, it is important to realize that any transition from a water-based organism to an air-breathing land-based organism would also require thousands of simultaneous mutations in the basic physiology of the eyes, nose, alimentary system, lungs, muscles, and bones. This would entail thousands of discrete mutations in the DNA, which would code for the underlying changes in the individual cellular systems and enzymes responsible for the changes. A transitional species change would also require a simultaneous change in another organism, allowing for reproduction and duplication of the markedly mutated DNA.
 
Figure 2
The Tiktaalik roseae proposed as the missing link between water-based and land-based organisms. Reprinted with permission from the New York Times.
 
The transitional species concept has been most extensively studied through invertebrate species of plants, shells, and mollusks in carefully preserved fossil fields in Japan, Malaysia, and Asia. Thousands of specimens were available at the time of Darwin. Millions of specimens have been classified and studied in the past 50 years. It is remarkable to note that each of these fossil beds shows a virtual explosion of nearly all phyla (35/40) of the animal kingdom over a relatively short period during the Cambrian era 525 to 530 million years ago (37) (Figure 3). Since that time, there has been occasional species extinction, but only rare new phyla have been convincingly identified (38). The seminal paper from paleoanthropologists J. Valentine and D. H. Erwin notes that the absence of transitional species for any of the Cambrian phyla limits the neo-Darwinian explanation for evolution (39).

Figure 3
The origin of the phyla: the fossil evidence. Contrary to both Darwinian gradualism and punctuated equilibria theory, the vast majority of phyla appear abruptly with low species diversity. The disparity of the higher taxa precedes the diversity of the ...
 
Finally, bacterial evolution or adaptation offers an excellent opportunity to see mutation in a species with rapid cell division. Evolutionary biology can be modeled over a relatively short time (30 years), while observing DNA mutations over 1020 generations (40). 
 This is analogous to observing mutations in man or any mammal over 200 million years. 
A recent review of numerous papers related to viral and bacterial evolution over the past 40 years revealed that the vast majority of mutations led to a loss or slight modification of function that conferred resistance or survival benefit (41). 
These specific mutations included simple deletions, substitutions, frame shift mutations, inversion, and insertion. No gain-in-function mutations were observed in any of the long-term bacterial evolution studies. There were only two gain-of-function mutations in the long-term viral evolution studies. The absence of mutations leading to a single new protein suggests the difficulty of using mutation to explain the development of numerous new proteins coded specifically by thousands of nucleotides in a precise order, interacting with numerous other enzymes in a simultaneous fashion to accomplish a single cellular action such as the cellular manufacture of a single nucleotide.

The complexity of creating two sequential or simultaneous mutations that would confer improved survival has been studied in the malaria parasite when exposed to chloroquine. The actual incidence of two base-pair mutations leading to two changed amino acids leading to resistance has been shown to be 1 in 1020 cases (42). To better understand this incidence, the likelihood that Homo sapiens would achieve any single mutation of the kind required for malaria to become resistant to chloroquine (a simple shift of two amino acids) would be 100 million times 10 million years (many times the age of the universe). This example has been used to further explain the difficulty in managing more than one mutation to achieve benefit.

In all fairness, there is convincing evidence, that is widely acknowledged, that random mutation and natural adaptation (Darwinian evolution) does occur within species, leading to minor changes in areas such as beak size, skin pigmentation, or antibiotic resistance. Some of these changes involve a simple biologic survival advantage for a population, without a mutation in DNA. Others might be influenced by a single deletion or insertion within the DNA strand. 
However, the modern evolution data do not convincingly support a transition from a fish to an amphibian, which would require a massive amount of new enzymes, protein systems, organ systems, chromosomes, and formation of new strands of specifically coding DNA. 

Even with thousands of billions of generations, experience shows that new complex biological features that require multiple mutations to confer a benefit do not arise by natural selection and random mutation. New genes are difficult to evolve. The bacteria do not form into other species. A reliance on gross morphologic appearances, as with fossils, drawings, and bone reconstructions, is severely inadequate compared to an understanding of the complexity of the DNA and coding that would have been required to mutate from a fish to an amphibian or from a primitive primate to a human.

PARADIGM SHIFT

In his landmark book, The Structure of Scientific Revolutions, Massachusetts Institute of Technology Professor Thomas S. Kuhn gave the term paradigm its contemporary meaning when he used it to describe universally recognized scientific achievements that, for a time, provide model problems and solutions to a community of practitioners (43). 
A paradigm shift can be heralded by the occurrence of “counterinstances or anomalies,” which represent exceptions of the logic or exaggerations of the evidence. 
According to Kuhn, these shifts lead to conflict, debate, and great resistance, even with accusations that the new theorists have ignored “science.” 
Examples of these gradual paradigm shifts, which began as chinks in the established armor of science, include Copernicus versus Ptolemy in astronomy, Lavoisier versus Priestly in gases, and Einstein versus Newton in relative dynamics.

The primary conflicts or anomalies with neo-Darwinian evolution lie in the failure of mutation and natural selection to account for the formation of DNA, the information of DNA, or the complexity of the human cell. 
In all fairness, many physicians, medical students, and college students have not been shown the weakness of Darwinian evolution. 
They haven't been shown the failure of the Miller-Urey experiments to explain DNA, RNA, or protein formation; the paucity of fossil data; or the refutations of transitional species based on a growing biochemical understanding of complex systems and the limits of DNA mutation to account for the formation of new DNA, new chromosomes, and therefore new species.
In contrast, how is it possible that the majority of National Academy of Science members (who should know the above weaknesses) fully believe that random mutation and natural selection can explain the origin of DNA and the subsequent generation of a vast array of protein systems within complex cells? It is possible that the biologist, the paleontologist, and the anthropologist are each studying a small portion of the picture and do not have the education and training to see the full picture. More likely, their previous research relies on the established paradigm of Darwinian evolution to provide structure for their work. As the limitations of existing paradigms become apparent, adoption of a new paradigm typically requires at least a full generation, since existing practitioners and scientists often hold on to the old paradigm.

When the Texas State Board of Education voted to recognize the weaknesses of Darwinian evolution in explaining the origin of the species, it was a result of 3 full days of intense debate and scientific dispute. In 2011, when new textbooks were presented to the State Board of Education, 9 out of 10 failed to provide the mandated supplementary curricula, which would include both positive and negative aspects of evolution (44). 
Moreover, several of the textbooks continued to incorrectly promote the debunked Miller-Urey origin of life experiment, the long-discredited claims about nonfunctional appendix and tonsils, and the fraudulent embryo drawings from Ernst Haeckel. In essence, current biology students, aspiring medical students, and future scientists are not being taught the whole story. Rather, evidence suggests that they continue to receive incorrect and incomplete material that exaggerates the effect of random mutation and natural selection to account for DNA, the cell, or the transition from species to species.

The Texas State Board of Education guidelines do not propose teaching any other alternatives to Darwinian evolution. Rather, the students of tomorrow and teachers of today should appropriately recognize that there are weaknesses that have been pointed out by reasonable scientists. 
In this dissection of Darwinism, we have cut into the weaknesses of the fossil evidence for human evolution, the failure of the fossil data to demonstrate substantial transition species, and the awareness of the sudden formation of most species in a short window of time, with no significant subsequent variation. More importantly, this physician-perspective article emphasizes the extreme impossibility of the natural formation or self-formation of billions of nucleotides in a specific sequence, allowing for the coding of RNA and proteins in a complex cell with thousands of interrelated and irreducibly complex functions. 
The article also enlightens the reader regarding the conflicts and difficulty of using natural selection and mutation to explain the simultaneous or sequential changes in cellular DNA, involving entirely new strands of DNA and thousands of new proteins, which are necessary for the formation of new species.
John Hunter and Charles Darwin were limited to gross observation of physical appearance. The human cell appeared to be a glob of jelly under a primitive microscope. Both scientists observed mutation and adaptation, which clearly exist today. 
For almost 150 years following their proposal, thousands of articles and biology departments across the world made observations based on the paradigm of random mutation and natural selection to account for changes within species. These changes are uncontested truths. 
 However, regarding the origin of the species and life (DNA), even Darwin commented, “If it could be shown that complex systems could not arise by small sequential steps, then my theory would completely break down.” 
Irreducibly complex systems involving thousands of interrelated specifically coded enzymes do exist in every organ of the human body. 
At an absolute minimum, the inconceivable self-formation of DNA and the inability to explain the incredible information contained in DNA represent fatal defects in the concept of mutation and natural selection to account for the origin of life and the origin of DNA. 
As new theories emerge that explain the origin of life, the inevitable emotional accusations of heresy and ignorance are not surprising in a period of scientific revolution. It is therefore time to sharpen the minds of students, biologists, and physicians for the possibility of a new paradigm.

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24. Mora PT. The folly of probability. In: Fox SW, editor. The Origins of Prebiological Systems and of Their Molecular Matrices. New York: Academic Press; 1965. pp. 39–64.
25. Dembski W. Design Inference. Cambridge, UK: Cambridge University Press; 1998. Eliminating chance through small probabilities; pp. 67–91. 175–223.
26. Meyer SC. Signature in the Cell. New York: Harper Collins; 2009. The double helix; pp. 58–84.
27. Nilsson DE, Pelger S. A pessimistic estimate of the time required for an eye to evolve. Proc Biol Sci. 1994;256(1345):53–58. [PubMed]
28. Berlinski D. A scientific scandal [commentary]. Seattle, WA: Discovery Institute Center for Science and Culture. Available at http://www.discovery.org/a/1408; retrieved September 12, 2011.
29. Behe MJ. Darwin's Black Box: The Biochemical Challenge to Evolution. New York: Free Press; 1996.
30. Meyer SC. Signature in the Cell: DNA and the Evidence for Intelligent Design. New York: HarperCollins; 2009. p. 365.
31. Simmons G. What Darwin Didn't Know: A Doctor Dissects the Theory of Evolution. Eugene, OR: Harvest Publishers; 2004.
32. Cremo MA, Thompson RL. Forbidden Archeology. San Diego, CA: Bhaktivedanta Institute; 1993.
33. Wells J. The Myth of Junk DNA. Seattle, WA: Discovery Institute Press; 2011.
34. Chimpanzee Sequencing and Analysis Consortium Initial sequence of the chimpanzee genome and comparison with the human genome. Nature. 2005;437(7055):69–87. [PubMed]
35. Durrett R, Schmidt D. Waiting for two mutations: with applications to regulatory sequence evolution and the limits of Darwinian evolution. Genetics. 2008;180(3):1501–1509. [PMC free article] [PubMed]
36. Luskin C. Tiktaalik roseae: where's the wrist? (updated). Evolution News and Views, July 14, 2008. Available at http://www.evolutionnews.org/2008/07/tiktaalik_roseae_wheres_the_wr008921.html; retrieved September 12, 2011.
37. Meyer SC, Ross R, Nelson P, Shien P. The Cambrian explosion: biology's big bang. In: Campbell J, Meyer SC, editors. Darwinism, Designs, and Public Education. East Lansing, MI: Michigan State University Press; 2003. pp. 323–401.
38. Stanley S. Macroevolution Pattern and Process. San Francisco, CA: Freeman Press; 1979. p. 39.
39. Valentine JW, Erwin DH. Interpreting great developmental experiments: the fossil record. In: Raff RA, Raff EC, editors. Development as an Evolutionary Process. New York: Alan R. Liss; 1987. pp. 74–96.
40. Linton A. Scant search for the maker. The Times Higher Education Supplement, April 20, 2001, Book Section, p. 29.
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42. Behe MJ. The Edge of Evolution. New York: Free Press; 2007. pp. 60–65.
43. Kuhn TS. The Structure of Scientific Revolutions. Chicago, IL: University of Chicago Press; 1970.
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David Berlinski : The Scientific Embrace of Atheism

 

The Scientific Embrace of Atheism

At sometime after the Russian cosmonaut Yuri Gagarin first entered space, stories began to circulate that he had been given secret instructions by the Politburo. Have a look around, they told him. Suitably instructed, Gagarin looked around. When he returned without having seen the face of God, satisfaction in high circles was considerable.
The commissars having vacated the scene, it is the scientific community that has acquired their authority. Richard Dawkins, Daniel Dennett, Stephen Weinberg, Vic Stenger, Sam Harris, and most recently the mathematician John Paulos, have had a look around: They haven't seen a thing. No one could have seen less.
It is curious that so many scientists should have recently embraced atheism. The great physical scientists -- Copernicus, Kepler, Galileo, Newton, Clerk Maxwell, Albert Einstein -- were either men of religious commitment or religious sensibility.
The distinguished physicist Steven Weinberg has acknowledged that this is what the great scientists believed: But we know better, he has insisted, because we know more.

This prompts the obvious question: Just what have scientists learned that might persuade the rest of us that they know better? It is not, presumably, the chemistry of Boron salts that has done the heavy lifting.

There is quantum cosmology, I suppose, a discipline in which the mysteries of quantum mechanics are devoted to the question of how the universe arose or whether it arose at all. 
This is the subject made popular in Stephen Hawking's A Brief History of Time. 
It is an undertaking radiant in its incoherence. Given the account of creation offered in Genesis and the account offered in A Brief History of Time, I know of no sane man who would hesitate between the two.

And there is Darwin's theory of evolution. It has been Darwin, Richard Dawkins remarked, that has made it possible to be an intellectually fulfilled atheist.

A much better case might be made in the other direction. It is atheism that makes it possible for a man to be an intellectually fulfilled Darwinist. In the documentary Expelled, one of those curious exercises in which some scientists, at least, say what they really think, Ben Stein interviews a number of Darwinian biologists eager to evade the evidence whenever possible or to ignore it when not. Rich in self-satisfaction, Dawkins appears at the film's end.

How did life on earth arise?
The question, Dawkins acknowledges, is very difficult.
Perhaps the seeds of life were sent here from outer space?
It could well be.
Or by a vastly superior intelligence?
Well, yes.
Questions and their answers follow one another, but in the end Stein says nothing. There is no absurdity Dawkins is not prepared to embrace so long as he can avoid a transcendental inference.

Beyond quantum cosmology and Darwinian biology -- the halt and the lame -- there is the solemn metaphysical aura of science itself. It is precisely the aura to which so many scientists reverently appeal. The philosopher John Searle has seen the aura. The "universe," he has written, "consists of matter, and systems defined by causal relations."
Does it indeed? If so, then God must be nothing more than another material object, a class that includes stars, starlets and solitons. If not, what reason do we have to suppose that God might not exist?

We have no reason whatsoever. If neither the sciences nor its aura have demonstrated any conclusion of interest about the existence of God, why then is atheism valued among scientists?

It takes no very refined analytic effort to determine why Soviet Commissars should have regarded themselves as atheists. They were unwilling to countenance a power higher than their own. Who knows what mischief Soviet citizens might have conceived had they imagined that the Politburo was not, after all, infallible?

By the same token, it requires no very great analytic effort to understand why the scientific community should find atheism so attractive a doctrine. At a time when otherwise sober individuals are inclined to believe that too much of science is too much like a racket, it is only sensible for scientists to suggest aggressively that no power exceeds their own.


David Berlinski is the author of the recently released The Devil's Delusion: Atheism and its Scientific Pretensions, as well as many books about mathematics and the sciences. A Ph.D. from Princeton University, he has taught at colleges and universities in the United States and France, and now lives in Paris. 

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Monday, March 13, 2017

Robert M. Price : Paradigm Shifting and the Apologetics Debate

Paradigm Shifting and the Apologetics Debate

By Robert M. Price

 
Of late, a new piece of jargon has intruded itself into discussions of theological and religious language. The newcomer is the “paradigm.” One may find this concept, borrowed from the philosophy of science, in theologi­cal works as far removed from each other as Thomas Torrance’s Theologi­cal Science and Charles Kraft's Christianity in Culture. It seems safe to suggest that the recent currency of this term and its attendant concept is in large part due to the efforts of Thomas S. Kuhn. Though Kuhn himself is a philosopher of science, the relevance of his work for other fields such as theology has become apparent. We would like to suggest the utility of his theory for the field of evangelical apologetics. More specifically, his schema of “paradigm-shifting" will be shown to provide the key for grasping the differences in the evidentialist vs. presuppositionalist debate in apologetics.

In his The Structure of Scientific Revolutions, Kuhn takes issue with the common conception that scientific advancement has proceeded mainly by way of "new discoveries.” In fact, really new data is relatively seldom discovered. Scientific progress has more to do with scientists coming to formulate new ways of construing the same old information, new keys to solve the puzzles presented by the data. One such paradigm will be accepted by scientists as long as it seems to make plausible sense of most of the evidence. Only when the paradigm starts to appear inadequate to the task of explaining this or that phenomenon do scientists begin looking for an alternative gestalt. The new paradigm will seek to incorporate much of the explicative power of the old, yet starting from at least a slightly different point, so as to deal plausibly with more of the hitherto-troublesome data. When the cogency and comprehensiveness of a new proffered paradigm becomes evident, a "paradigm- shift" occurs. The new model for construing the data becomes the basis for the next stage of theorizing and research. Of course the likelihood is that it, too, will be superseded in time.
To give a famous example seen through the lenses provided by Kuhn, we will look at the contest between the geocentric paradigm of Ptolemy and the heliocentric paradigm of Copernicus. Ptolemy's model of the planetary system functioned well enough to predict the motion of the (apparently earth­ orbiting) planets, but it ran into trouble when it came to the mysterious retrograde motion of the planets. In order for the geocentric model to predict accurately these erratic movements (hitherto considered to be the "free will" of the planets), Ptolemaic astronomers had to postulate myriad series of "epicycles,” or wheels within hypothetical wheels on which the planets turned. Copernicus found that the whole system might be simplified by postulating that the sun, not the earth, was the center of planetary orbit. This way all the epicycles disappeared.
Eventually Copernicus’s view became dominant. It wasn't that Copernicus had somehow “discovered” the earth to be orbiting the sun instead of the other way around. Such a thing would have been (and probably still is) incapable of observation. Rather, he merely formulated a new gestalt for the data which made its explanation less problematic, more natural, than before. And this is basically the way all scientific progress comes about, by a "conversion”1 from one paradigm to another.

But there is an important tension, often unnoticed, in Kuhn's schema. Are paradigms self-sealing? That is, do they carry their own criteria of plausibility of explanation? Mustn't they, if they are truly comprehensive systems for understanding data (so that only in light of them are the data "data for" anything)? But if they do, then how is any shift from one para­digm to another ever possible? In terms of our example, why should Ptolemaists have felt ashamed of all those epicycles? Given the fundamental postulate, geocentricity, there could be nothing embarrassing or implausible about the resulting complexities. Why should not things be complex? If the paradigm itself carries its own criteria of plausibility, then any explanation assigned to “problematic” (or “anomalous”) data must ipso facto be plausible.

But of course, the shift did occur. This implies that paradigms do not contain within themselves their own criteria of plausibility. And if they do not, they must be seen as sub-paradigms, or subsets of a larger, all­ comprehensive paradigm. This super-paradigm will be the field of presuppositions in which scientific thought occurs. It will include criteria by which given sub-paradigms (geocentricity or heliocentricity, Einsteinian or Newtonian physics, Big Bang or steady-state cosmologies) can be preferred to one another. Included among these criteria would probably be something like “economy and inductivemess of explicability of the data.” Such criteria will be the arbiters of which paradigm makes “better sense” of the evidence. They will tell which sense is the “better” sense. 

This issue, merely implicit in Kuhn's discussion, is raised explicitly (albeit in different terminology) in the long-standing debate between "evidentialist" apologists (Clark Pinnock, John Warwick Montgomery, Josh  McDowell, etc.) on the one hand, and their "presuppositionalist" rivals (Cornelius Van Til, Gordon Clark, etc.) on the other. In this context, the issue is that of "common ground," i.e., does any exist between believers and non-believers?

 Evidentialists build their whole enterprise on a positive answer to this question. Indeed, they say, there can properly be no apologetics at all unless some commonly-acknowledged criteria exist, whereby the evangelical position may be rendered probable or compelling to the fair-minded non-believer. Before examining the presuppositionalist objection to this belief, let us analyze the evidentialist position further in the light of Kuhn's categories. In effect, the evidentialists assume that they and their imagined non-Christian partners in dialogue both assent to a "super-paradigm" of criteria for plausibility and explicability. The same kinds of grounds will determine which is the "better" sense made of the evidence. By their amassing of evidence, what McDowell, Montgomery, Pinnock, et. al., seek to do is to show that the secular naturalists' paradigm cannot adequately (plausibly) explain "anomalous data" like, e.g., the empty tomb. This is the point of the stock rehearsals of how "no explanation fits the facts of Easter Morning as well as the Resurrection does." The naturalists' explanations "demand more faith than the Resurrection itself" (Montgomery)2 That is, the “Swoon theory," the “wrong tomb theory," etc., are like epicycles. They are implausible. What makes them implausible? A common set of criteria including the notion that eyewitness reporting is valid, that crucified but surviving men are not likely to be able to roll away stones and stagger into Jerusalem, etc. So no matter how much the skeptic cherishes his naturalistic paradigm, he really should admit its inadequacy to explain the evidence of Easter Morning. He should convert his paradigm (and with it, in this case, his eternal destiny). 
 
Presuppositionalists, of whom we may take Van Til as the paramount example, repudiate this whole approach. There can be no common ground, he insists, because of the "noetic effects of the fall.” It is a fundamental mistake to imagine that (Christ- rejecting) unregenerate persons can perceive enough of the facts correctly to be led from them (the common ground) to faith in Christ.3 No, “all things hold together in Him” (Colossians 1:17). Since every single fact is to be properly construed only in the light of faith in Christ, then any perception by a Christ-rejecting (or Christ-blind) person is a misapprehension, even a delusion. Leaving aside the fact that this is pretty much the same rationale that has led historically to the branding and treatment of religious dissidents as insane, we will proceed to develop our interpretation of this view in Kuhn’s terms. Van Til is essentially arguing that paradigms are self-sealing. They must carry their own criteria for plausibility within themselves, so that whatever explanation assigned to a datum is ipso facto plausible and natural. The apologetical / epistemological meaning of this is that religious certainty may be achieved only if it is defined into the system from the start. One can never reason his way to certain faith in Christ; he may only have certainty if he begins by defining Christ (the Logos) as the ground of reason. Then by definition faith in Christ is not only "a reasonable option," it becomes the only rational option. 
The evidentialist approach is unsatisfactory at least partially because it makes the Christ-Logos posterior rather than anterior to the reasoning process. In Kuhn's terms, evidential apologetics makes the evangelical Christian sub­paradigm subordinate to the larger paradigm of neutral, common criteria. And if it does this, then the same bridge from one sub-paradigm to the evangelical one, could as easily one day be the bridge to still a third sub­paradigm. The facts might lead the Christian elsewhere. Theoretically, this possibility must be left open. And what kind of faith-certitude would this be? 

Evidentialists like Pinnock reply that such absolute theoretical certainty is neither available nor necessary to live any other area of life, so why here? We can have practical certainty. As Gordon J. Allport observes,  
The believer is often closer to the agnostic than we think. Both, with equal candor, may concede that the nature of Being cannot be known [with absolute certainty]; but the believer, banking on a probability. . . finds that the energy engendered and the values conserved prove the superiority of affirmation over indecisiveness.4 
 
However, as full of common sense as the evidentialist position seems to be, the presuppositionalist critique is still a good one. Acquaintance with the literature of evidentialist apologetics makes it clear that their religious faith is more certain than is allowed by their common-ground approach with its inherent provisionality. For instance, John Warwick Montgomery writes of the doctrine of the Trinity, "I believe it with all my heart. I believe it because... it offers the best available ‘construct' or 'model' for interpret­ing the biblical descriptions of God as Creator, Redeemer, and Sanctifier.”5 Can one appropriately cling to a (mere) "model" or paradigm with "all one's heart"? Or to put it another way, can anyone reading such a statement really envision any rival interpretation of the evidence changing Montgomery's mind? Along the same lines, it is clear from a reading of much evidentialist literature that facts have been amassed to buttress beliefs already held on other grounds, and by willpower.6 A subtle shifting of ground occurs. The apologist's faith causes him to deem “best" the reading of the data most in accord with his beliefs, even if it must be harmonized. But he proceeds to offer this reading to the non-believer as if it were the best reading of the facts in and of themselves. He claims to appeal to "common ground!' (e.g., "economy and inductiveness of explanation") but actually appeals to partisan criteria (e. g., "which reading of biblical criticism conforms to evangelical beliefs?").This results in what James Barr has called "maximal conserva­tism,” the serving of a hidden dogmatic agenda.7 The presuppositionalists, on the other hand, are quite open about their dogmatic agenda. They drop the pretense of a "common ground" and admit that the paradigm is self-sealing. 

We have just suggested that, like their presuppositionalist rivals, the evidentialists actually seem to place their faith anterior to argumentation, though their principles call for the placing of it posterior to argumentation. (Both then are really in effect “presuppositionalists," though one side doesn't realize it.) And this inconsistency is no accident. Indeed if one thinks to use a truly evidentialist approach, he is dooming his apologetics from the start. There is something inherent in the common-criteria approach that makes its use in apologetics fundamentally wrong-headed. 

Basically the trouble is that the only common ground is contemporary human experience of the world. (In terms of our discussion of paradigms, this is the same as "economic and inductive explanation" of the data at hand, without recourse to extraneous hypotheses.). Historical critics have a term for this: "the principle of analogy," as formulated by Ernst Troeltsch.8 This principle, the basis of the historical-critical method's “denial of the miraculous," is a red flag to evangelicals. Yet they use exactly the same principle, only with a different name and applied to different cases. 
This is the common "empirical fit" argument used by Francis Schaeffer and Os Guiness to write off Eastern religions as failing to ring true to the depths of human experience.9 In both cases, the idea is that, though theoretically anything (ancient miracle stories or modern philosophical worldviews) is quite possibly true, there is no available criterion for plausibility except present, shared human experience. This is why users of electric lights and radio may have trouble accepting the miracles of the New Testament. This is why those who know suffering or love may find it difficult to accept the Eastern denial of the reality of these things. If the "common-ground" or “empirical fit" argument works at all, it works too well. Consistently pursued, such an inductive approach could of course lead only to some kind of natural theology, not to a "revealed religion" like evangelical Christianity. 
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Now if "common ground" is a chimera for apologetics, on what basis may the outsider opt for revealed religion? The evangelistic appeal of a consistent presuppositionalist must seem (from the human side) as a "leap of faith." And what the prospective convert sees, that the apologist-evangelist may not, is that this is only one of several invitations to leap in several  directions. And the leap is “known” (felt) to be the right one after the choice has been made ("I once was blind, but now I see"). Before the fact, how is he to decide which faith to leap into? Walter Kaufmann said it well:
  
They say their doctrine is infallible and true, but ignore the fact that there is no dearth whatsoever of pretenders to infallibility and truth.... scores of other doctrines, scriptures, and apostles, sects and parties, cranks and sages make the same claim.... Those who have no such exalted notion of themselves have no way of deciding between dozens of pretenders if reason is proscribed [i.e., if common ground criteria are disallowed because of the “noetic effects of. the fall"].10
  
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Quite a dilemma! The common ground approach can never lead to conviction, but the presuppositionalist “leap of faith" could lead to Jim Jones as easily as to Jesus Christ! How could one decide? "Revolutionary suicide” in a Guyana rainforest is quite reasonable once one accepts the proper presup­positions. If one flinches because "obviously that's pathological," isn't he holding out on his piece of common ground, just like the unbelieving skeptic who judges the cross to be foolishness? If we cast away everyday experience as our standard of judgment, there can be no standard of judgment until after we make the leap of faith. But we could make that leap in any direction. And after we made it, it would seem right. The paradigm would carry with it its own criteria. 
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The upshot of all this is that the evidentialist apologetic with its common ground approach finally backfires. A really inductive approach to this- worldly evidence can lead one only to this-worldly (i.e., non-revealed) religion. The presuppositionalist apologetic is consistent but not at all compelling, since the immunity from doubt that it wins for those inside the circle of faith simultaneously cancels its attraction to those outside. It can look neither more nor less plausible since there is no standard with which it may be compared. And the same approach is amenable to every sect. But the evangelical Christian (or believer in any sect) does not need to trouble himself about this. If he is safely within the circle of the truth himself, he can simply dismiss the other sects. And as for the outsider, doesn't the believer trust in the Spirit's conviction--if not actual predestination, then at least prevenient grace?11 Then why worry about common ground, or for that matter about apologetics at all? Believers may plant the seed, but isn't it up to God to give the harvest (1 Corinthians 3:6-7)? Shouldn’t faith rest on God's Spirit, not the persuasive words of man's wisdom (1 Corinthians 2:4)? Shouldn't it be revealed by the Father in heaven, not by flesh and blood (Matthew 16: 17)?
And, finally, seen from the outsider's perspective, it would have to be said that the way to certain faith is an overwhelming "final experience," an enlightenment. Though the question of rational certitude is not theoretically solved, it is psychologically settled, since the new believer will no longer care to ask it. Now he knows

By raising the question of the structure of paradigm-shifts and how they are possible, Thomas S. Kuhn has provided a set of categories with which better to understand the long-standing apologetics debate. When seen in terms of his theory, the two apologetical strategies presently dominant in evangelical circles, the evidentialist and the presuppositionalist, seem to be beset with surprising difficulties. In fact, these difficulties run so deep as to indicate that the only consistent apologetic is fideistic presuppositionalism, which is in a sense no apologetic at all, since on principle it removes any external standards by which its faith might be “vindicated” or “defended.”
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NOTES 
1 Thomas S. Kuhn, The Structure of Scientific Revolutions (Chicago: University of Chicago Press, 1969), p. 150.  
2 John Warwick Montgomery, The Suicide of Christian Theology (Minneapolis: Bethany Fellowship, 1975), p. 39. This line of reasoning is to be found in a large number of books, and with very little variation. See, for example, John Stott's Basic Christianity; J. N. D. Anderson's The Evidence for the Resurrection; Michael Green's Man Alive!; Josh McDowell's Evidence That Demands A Verdict; Clark Pinnock's Set Forth Your Case
3 Among Van Til’s many works, see for example The Protestant Doctrine of Scripture ([n.p.] Den Dulk Christian Foundation, 1967), p. 11: "one must be a believing Christian to study nature in the proper frame of mind and with proper procedure." 
4 Gordon J. Allport, The Individual and his Religion (New York: Macmillan Publishing Company, 1974), p. 83. 
5 Montgomery in Robert Campbell (ed.), Spectrum of Protestant Beliefs (Milwaukee: Bruce Publishing Company, 1968), p. 20. 
6 This assertion, I realize, invites a full-scale demonstration for which there is no space here. Basically, let me say that much apologetic argumen­tation for, e.g., the total reliability of the gospels as historical records, and for the historicity of the resurrection, are totally out of date and do not come to grips realistically with modern biblical criticism. This is true even of such recent works as Josh McDowell's More Evidence That Demands A Verdict and Buell and Hyder’s Jesus:  God, Ghost or Guru? The interested reader may find a full-scale treatment of these questions in my Beyond Born Again
7 See his incisive work Fundamentalism (Philadelphia: Westminster Press, 1978). 
8 For two clear and sympathetic treatments of the principle of analogy, see Van A. Harvey, The Historian & The Believer (New York: Macmil­lan Company, 1972); and F.. H. Bradley, The Presuppositions of Critical History (Chicago: Quadrange Books, 1968). 
9 See, for example, Francis Schaeffer's The God Who is There (Downer's Grove, Illinois: InterVarsity Press, 1968); Escape from Reason (Downer's Grove, Illinois: Inter Varsity Press, 1968); and Os Guiness, The Dust of Death (Downer's Grove, Illinois: InterVarsity Press; 1973). Shaeffer's and Guiness's use of this argument, incidentally, shows them to be less consistently presuppositionalist than Van Til. 
10 Walter Kaufmann, The Faith of a Heretic (Garden City, New York: Doubleday & Company, Inc., 1963), p. 86. 
11 Van Til certainly does: "And it is only when the Holy Spirit gives man a new heart that he will accept the evidence of Scripture about itself and about nature for what it really is. The Holy Spirit's regenerating power enables man to place all things in true perspective." (Protestant Doctrine of Scripture, pp. 10-11).

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